|
KMID : 0361520080190050266
|
|
Korean Journal of Psychopharmacology
2008 Volume.19 No. 5 p.266 ~ p.275
|
|
|
An Association Study between Various Monoamine Transporter Gene Polymorphisms and Treatment Response to Mirtazapine in Major Depression
|
|
Choi Hong
Lim Shinn-Won
Kim Su-Yeon
Kim Hye-Ran
Chung Jae-Won
Kim Doh-Kwan
|
|
|
Abstract
|
|
|
Objective : Genetic differences may contribute to the inter-individual differences in treatment response to antidepressants among patients suffering from major depression. This study investigated a possible association of various monoamine transporter genetic polymorphisms with treatment response to mirtazapine in major depressive patients in elderly.
Methods : In this study, three genetic polymorphisms were selected : serotonin transporter 5-HTILPR, serotonin transporter 5-HTT intron 2 VNTR, and norepinephrine transporter NET (G1287A). The patients with major depression diagnosed by DSM-Ⅳ were recruited to a 6 week naturalistic mirtazapine treatment study in Samsung Medical Center. Treatment response to mirtazapine was defined as ≥50% decrease in HAMD-17 scores at 6 weeks, and the genotypes in the patients were determined using the polymerase chain reaction.
Results : Our results showed that ss allele carriers were included more in responder group (ss allele in responder vs. non responder group ; 69.4% vs. 40.0%). In addition, 1-allele (sl/ll) carriers were included less in responder group (sl/ll allele in responder vs. non responder group ; 30.6% vs. 60.0%). Multiple logistic regression analyses showed the 5-HTILPR polymorphism as an predictor of the mirtazapine response (5HTILPR ss allele carrier vs. l-allele (sl/ll) carrier ; odds ratio : 3.81 ; 95% confidence interval [CI], 1.32-11.0 ; p=0.013). However, 5-HTT intron 2 VNTR 1/s (p=0.33 by multiple logistic regression ; [OR], 0.53 ; 95% [CI], 0.15-1.88), and NET (G1287A) G/A (p=0.68 by multiple logistic regression ; [OR], 1.25 ; 95% [CI], 0.44-3.53) showed no statistical significant influences on response rate.
Conclusion : In conclusion, 5HTILPR polymorphism may predict treatment response to mirtazapine in major depressive patients in elderly.
|
|
|
KEYWORD
|
|
|
Mirtazapine, Genetic polymorphism, Major depression, Serotonin transporter, Norepinephrine transporter
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|